BC 079 – Daraxonrasib ou chimiothérapie dans le cancer du pancréas métastatique déjà traité (étude RASolute 302)

Épisode de BaladoCritique - club de lecture médical par Dr Luc Lanthier et collaborateurs · 23 août 2026 · 40 min

Dans cette 79e baladodiffusion, les Drs Luc Lanthier et Giulia Pool discutent d’une nouveauté thérapeutique en cancer du pancréas, en plus de réviser la littérature médicale de mai, juin et juillet 2026.

Quiz clinique (2 min 05), présentation principale (2 min 35), critique (22 min 32), retour sur le cas clinique (28 min 04), autres articles (29 min 32), réponse au quiz clinique (36 min 35).

Référence principale :

O’Reilly EM, Wainberg ZA, Hendifar AE, Borad MJ, Pietrantonio F, Pant S, et al. Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer. N Engl J Med. 2026;395(4):325-37. PubMed PMID: 42223072.

Articles associés :

Teede HJ, Khomami MB, Morman R, Laven JSE, Joham AE, Costello MF, et al. Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process. Lancet. 2026;407(10545):2329-39. PubMed PMID: 42119588.

Stoop TF, Javed AA, Oba A, Koerkamp BG, Seufferlein T, Wilmink JW, et al. Pancreatic cancer. Lancet. 2025;405(10485):1182-202. PubMed PMID: 40187844.

Der CJ, Yeh JJ. Advances in RAS Therapeutics for Pancreatic Cancer. N Engl J Med. 2026;394(18):1857-1861. PubMed PMID: 42090797.

Wolpin BM, Park W, Garrido-Laguna I, Spira A, Starodub A, Sommerhalder D, et al. Daraxonrasib in Previously Treated Advanced RAS-Mutated Pancreatic Cancer. N Engl J Med. 2026;394(18):1790-802. PubMed PMID: 42090791.

Sivakumar S. Breaking the RAS Barrier in Pancreatic Cancer. N Engl J Med. 2026;395(4):400-1. PubMed PMID: 42485631.

Aronchik I, Kar S, Zhuang Y, Ahler E, Lai LP, Seshadri V, et al. Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer. Nat Med. 2026;32(8):2865-77. PubMed PMID: 42581230.

Autres articles d’intérêt récent :

Rosenfield K, Klok FA, Piazza G, Sharp ASP, Ni Ainle F, Jaff MR, et al. Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism. N Engl J Med. 2026;394(20):1979-90. PubMed PMID: 41910345.

Cummings JL, Atri A, Sano M, Zetterberg H, Scheltens P, Knop FK, et al. Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer’s disease (evoke and evoke+): two phase 3, randomised, placebo-controlled trials. Lancet. 2026;407(10544):2167-79. PubMed PMID: 41865758.

Hayden FG, Shinkai M, Clark TW, Luetkemeyer AF, Sax PE, Hanage WP, et al. Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts. N Engl J Med. 2026;394(19):1905-15. PubMed PMID: 42127390.

Houston BL, McIsaac DI, Breau RH, Kanji S, Greenstreet P, Andrews M, et al. Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery. N Engl J Med. 2026;394(24):2419-28. PubMed PMID: 42267805.

Hou J, Lim SG, Buti M, Yuen MF, Gane E, Lampertico P, et al. Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection. N Engl J Med. 2026;394(24):2395-406. PubMed PMID: 42206582.

Wazni OM, Chun KRJ, Nair DG, Anic A, Duytschaever M, Chrispin J, et al; AVANT GUARD Study Investigators. Pulsed Field Ablation as Initial Therapy for Persistent Atrial Fibrillation. N Engl J Med. 2026;394(24):2407-2418. PubMed PMID: 42041224.

Doshi SK, Kar S, Nair DG, Waggoner T, Agarwal H, Moussavian M, et al. Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation. N Engl J Med. 2026;394(21):2083-94. PubMed PMID: 41910347.

Staphylococcus aureus Network Adaptive Platform Trial G, Lee TC, Barina LA, Walls G, Goodman AL, Yahav D, et al. Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia. N Engl J Med. 2026;394(23):2329-39. PubMed PMID: 42308484.

Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group. Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia (SNAP): an international, multicentre, open-label, non-inferiority randomised controlled trial. Lancet. 2026;408(10550):141-152. PubMed PMID: 42309115.

Nathan SD, Smith P, Deng C, King CS, De Salvo M, Weigt SS, et al. Phase 3 Trials of Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis. N Engl J Med. 2026;395(2):115-26. PubMed PMID: 42149993.

Guides de pratique :

Smolen JS, Edwards CJ, Konzett V, Laskou F, Aletaha D, Caporali R, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biologic disease-modifying antirheumatic drugs: 2025 update. Ann Rheum Dis. 2026;85(6):991-1009. PubMed PMID: 41826212.

Peery AF, Strate LL, Stollman N, Mankaney G, Chang JW, Grover S. ACG Clinical Guideline: Colonic Diverticulitis. Am J Gastroenterol. 2026;121(7):1549-61. PubMed PMID: 42390126.

Writing Committee M, Ndumele CE, Rodriguez F, Dixon DL, Khan SS, Mukherjee D, et al. 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;154(4):e50-e158. PubMed PMID: 42263157.

Références du quiz clinique :

Richert Q, Miller N, Cameron S, Barr B, Nkosi J, Sharma A. Updates on Rhabdomyolysis: A Clinically Oriented Narrative Review. Chest. 2026;170(1):128-36. PubMed PMID: 41619932.

Cabral BMI, Edding SN, Portocarrero JP, Lerma EV. Rhabdomyolysis. Dis Mon. 2020;66(8):101015. PubMed PMID: 32532456.

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