BC 040 – Efficacité et sécurité de la sémaglutide chez les sujets avec embonpoint ou obésité (étude STEP1)

Épisode de BaladoCritique - club de lecture médical par Dr Luc Lanthier et collaborateurs · 25 mars 2021 · 51 min

Dans cette 40e baladodiffusion, les Drs Luc Lanthier et Marie-France Langlois discutent de sémaglutide dans le traitement de l’obésité, en plus de réviser la littérature médicale de janvier et février 2021.

Quiz clinique (4 min 50), 1e étude principale (5 min 17), 2e étude principale (27 min 18), critique (41 min 00), autres articles (53 min 15), réponse au quiz clinique (57 min 15)

Référence principale

Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989-1002. PubMed PMID: 33567185.

Articles associés

Wharton S, Lau DCW, Vallis M, Sharma AM, Biertho L, Campbell-Scherer D, et al. Obesity in adults: a clinical practice guideline. CMAJ. 2020;192(31):E875-E91. PubMed PMID : 32753461.

Ingelfinger JR, Rosen CJ. STEP 1 for Effective Weight Control – Another First Step? N Engl J Med. 2021;384(11):1066-1067. PubMed PMID: 33567184.

Latini R, Staszewsky L. Semaglutide and effective weight control. Lancet. 2021;397(10278):942-943. PubMed PMID: 33667415.

Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, et al; SCALE Obesity and Prediabetes NN8022-1839 Study Group. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015;373(1):11-22. PubMed PMID: 26132939.

Davies M, Færch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, et al; STEP 2 Study Group. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet. 2021;397(10278):971-984. PubMed PMID: 33667417.

Wadden TA, Bailey TS, Billings LK, Davies M, Frias JP, Koroleva A, et al; STEP 3 Investigators. Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial. JAMA. 2021 Feb 24:e211831. PubMed PMID: 33625476.

Kushner RF, Calanna S, Davies M, Dicker D, Garvey WT, Goldman B, et al. Semaglutide 2.4 mg for the Treatment of Obesity: Key Elements of the STEP Trials 1 to 5. Obesity (Silver Spring). 2020;28(6):1050-1061. PubMed PMID: 32441473.

https://obesitycanada.ca/

Autres articles d’intérêt

Couturaud F, Bertoletti L, Pastre J, Roy PM, Le Mao R, Gagnadoux F, et al. Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms. JAMA. 2021;325(1):59-68. PubMed PMID: 33399840.

Bhatt DL, Szarek M, Pitt B, Cannon CP, Leiter LA, McGuire DK, et al. Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease. N Engl J Med. 2021;384(2):129-39. PubMed PMID: 33200891.

Bhatt DL, Szarek M, Steg PG, Cannon CP, Leiter LA, McGuire DK, et al. Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure. N Engl J Med. 2021;384(2):117-28. PubMed PMID: 33200892.

Teerlink JR, Diaz R, Felker GM, McMurray JJV, Metra M, Solomon SD, et al. Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure. N Engl J Med. 2021;384(2):105-16. PubMed PMID: 33185990.

Wazni OM, Dandamudi G, Sood N, Hoyt R, Tyler J, Durrani S, et al. Cryoballoon Ablation as Initial Therapy for Atrial Fibrillation. N Engl J Med. 2021;384(4):316-24. PubMed PMID: 33197158.

Andrade JG, Wells GA, Deyell MW, Bennett M, Essebag V, Champagne J, et al. Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation. N Engl J Med. 2021;384(4):305-15. PubMed PMID: 33197159.

Ducrocq G, Gonzalez-Juanatey JR, Puymirat E, Lemesle G, Cachanado M, Durand-Zaleski I, et al; REALITY Investigators. Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial. JAMA. 2021;325(6):552-560. PubMed PMID: 33560322.

Herrett E, Williamson E, Brack K, Beaumont D, Perkins A, Thayne A, et al; StatinWISE Trial Group. Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials. BMJ. 2021;372:n135. PubMed PMID: 33627334.

Guides de pratique

Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, et al; ESC Scientific Document Group. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2021;42(5):373-498. PubMed PMID: 32860505.

Writing Committee Members, Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP 3rd, Gentile F, Jneid H, et al. 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2021;77(4):450-500. PubMed PMID: 33342587.

Lyman GH, Carrier M, Ay C, Di Nisio M, Hicks LK, Khorana AA, et al. American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. Blood Adv. 2021;5(4):927-974. PubMed PMID: 33570602.

Capsule méthodologique

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. PMID: 31462531.

Références du quiz clinique

Albassam OT, Redelmeier RJ, Shadowitz S, Husain AM, Simel D, Etchells EE. Did This Patient Have Cardiac Syncope?: The Rational Clinical Examination Systematic Review. JAMA. 2019;321(24):2448-2457. PMID: 31237649.

Sheldon R, Rose S, Ritchie D, Connolly SJ, Koshman ML, Lee MA, Frenneaux M, Fisher M, Murphy W. Historical criteria that distinguish syncope from seizures. J Am Coll Cardiol. 2002;40(1):142-8. PMID: 12103268.

Shmuely S, Bauer PR, van Zwet EW, van Dijk JG, Thijs RD. Differentiating motor phenomena in tilt-induced syncope and convulsive seizures. Neurology. 2018 Apr 10;90(15):e1339-e1346. PMID: 29549227.

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